A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer

The adsorption of iodine-125 on silver wire bits coated with palladium to be sealed in titanium capsules as brachytherapy sources was studied. A method was optimized to obtain quantitative adsorption of 125I on the palladium treated silver wires. A comparative evaluation of palladium coated and uncoated (bare) silver wires on the adsorption of 125I was made. While, the adsorption of bare silver wires showed low, inconsistent uptake (not, vert, similar60%) of 125I with high leachability (not, vert, similar4%), the Pd coated silver wires showed quantitative and consistent uptake of 125I (not, vert, similar90%) and exhibited low leachability (0.01%). 125I adsorbed on Pd coated silver wires could be used as a matrix for the preparation of interstitial sources in eye and prostate cancer therapy.