Title of article
Automation of [11C]acyl chloride syntheses using commercially available 11C-modules
Author/Authors
Mario Matarrese، نويسنده , , Francesco Sudati، نويسنده , , Dmitri Soloviev، نويسنده , , Sergio Todde، نويسنده , , Elia Anna Turolla، نويسنده , , Marzia Galli Kienle، نويسنده , , Ferruccio Fazio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
675
To page
679
Abstract
In implementing published procedures for the incorporation of [11C]carbon dioxide on the immobilized Grignard reagents for the radiosynthesis of [11C]acyl chlorides, several modifications on a commercial PET tracer synthesizer module for 11C-methylations were made to obtain reliable and reproducible production processes for routine clinical applications. High yields of [carbonyl-11C]WAY-100635 and [11C]zofenoprilat were obtained via 11C-carboxylation using [carbonyl-11C]cyclohexanecarbonyl chloride and 2-methyl-[1-11C]acryloyl chloride prepared with the modified module.
Keywords
PET , Immobilized Grignard reagents , Nuclear interface PET tracer synthesizer
Journal title
Applied Radiation and Isotopes
Serial Year
2002
Journal title
Applied Radiation and Isotopes
Record number
541352
Link To Document