Title of article :
Distribution of 16α-[18F]fluoro-estradiol-3,17β-disulfamate in rats, tumour-bearing mice and piglets
Author/Authors :
P. Brust، نويسنده , , H. Rodig، نويسنده , , J. R?mer، نويسنده , , H. Kasch، نويسنده , , R. Bergmann، نويسنده , , F. Füchtner، نويسنده , , D. Zips، نويسنده , , M. Baumann، نويسنده , , J. Steinbach، نويسنده , , B. Johannsen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Based on a high affinity to the enzyme estrone sulfatase (ES), 16α-[18F]fluoroestradiol-3,17β-disulfamate ([18F]FESDS) has been suggested as a potential PET radiotracer for imaging steroid-dependent breast tumours. The distribution of [18F]FESDS was studied in rats, tumour-bearing nude mice and piglets. In all species evidence for binding to a second target, the enzyme carbonic anhydrase (CA), was obtained. ES and CA inhibitors significantly reduced the radiotracer uptake in various organs but not in tumours. It is concluded that [18F]FESDS binds to ES and CA in vivo but this binding is not strong enough to allow tumour imaging with positron emission tomography (PET).
Keywords :
carbonic anhydrase , Disulfamate , Estrone sulfatase , positron emission tomography , steroids , 18F , tumour
Journal title :
Applied Radiation and Isotopes
Journal title :
Applied Radiation and Isotopes
