Title of article
Adduct of 2-[18F]FDG and 2-nitroimidazole as a putative radiotracer for the detection of hypoxia with PET: synthesis, in vitro- and in vivo-characterization
Author/Authors
Marianne Patt، نويسنده , , Dietlind Sorger، نويسنده , , Matthias Scheunemann، نويسنده , , Gerhard St?cklin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
8
From page
705
To page
712
Abstract
A new sugar-coupled 2-nitroimidazole derivative ([18F]image) has been prepared in good radiochemical yields starting from peracetylated 2-[18F]FDG obtained from an automated 2-[18F]FDG production module. The corresponding glucose derivative image has proved to be able to inhibit 2-[18F]FDG uptake into tumor cells in a concentration dependent way. However, [18F]image failed to show a retention in hypoxic tumor tissue thus excluding itself from further investigations.
Keywords
Hypoxia , phosphorylation , Hexokinase , Glucose transport , Fluorine-18 , 2-FDG , Nucleoside transport
Journal title
Applied Radiation and Isotopes
Serial Year
2002
Journal title
Applied Radiation and Isotopes
Record number
541356
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