Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB)

The three-step radiosynthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [18F]SFB was obtained in decay-corrected radiochemical yields of 34–38% (related to [18F]fluoride; n=12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93–96%.