Author/Authors :
J. Schmaljohann، نويسنده , , D. Gündisch، نويسنده , , M. Minnerop، نويسنده , , A. Joe، نويسنده , , J. Bucerius، نويسنده , , C. Dittmar، نويسنده , , F. Jessen، نويسنده , , S. Guhlke، نويسنده , , U. Wüllner، نويسنده ,
Abstract :
2-[18F]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of α4β2 nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[18F]F-A85380 by purification of the BOC-protected intermediate product with a combination of solid phase extraction cartridges. After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[18F]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes.
Keywords :
2-18F-A85380 , PET , Fluor-18 , Nicotinic acetylcholine receptor
