Characterization of hydrogels using nuclear magnetic resonance spectroscopy

Literature relevant to characterization of hydrogels and cross-linked polymer networks using nuclear magnetic resonance (NMR) spectroscopy has been extensively reviewed. After a brief introduction to the fundamentals of NMR spectroscopy, a variety of NMR techniques are considered, including 13C NMR of swollen polymer networks, end-group studies by 13C NMR with labelled initiators, spin-spin and spin-lattice relaxational studies to distinguish species based upon mobility, and characterization of specific interactions using the nuclear Overhauser effect. Finally, a brief treatment of the characterization of polymer structural quantities such as composition, tacticity and sequence distribution by NMR spectroscopic studies is presented. Although our discussion is representative rather than exhaustive, we are confident that this review will demonstrate the utility of NMR spectroscopy for characterization of hydrogel networks which have applications as biomaterials.