• Title of article

    Preparation of hydrogel microspheres by coacervation of aqueous polyphosphazene solutions

  • Author/Authors

    Alexander K. Andrianov، نويسنده , , Chen Jianping، نويسنده , , Lendon G. Payne، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1998
  • Pages
    7
  • From page
    109
  • To page
    115
  • Abstract
    A new method of preparing ionically cross-linked polyphosphazene hydrogel microspheres which enables effective control over microsphere size distribution has been developed. The synthesized microspheres can be used in protein delivery and, especially, as vaccine delivery vehicles. A new technique utilizes the ability of aqueous solutions of poly[di(carboxylatophenoxy)phosphazene] (PCPP) to form coacervate microdroplets upon addition of sodium chloride. These microdroplets are then stabilized via polymer cross-linking with calcium ions. It was demonstrated that the method enables efficient microencapsulation of proteins. It was also shown that microsphere size can be controlled through the manipulation of microencapsulation conditions. The process is simple, highly reproducible and generates microspheres with a narrower microsphere size distribution, compared to the previous technologies.
  • Keywords
    Polyphosphazene , Ionic cross-linking , Coacervation , hydrogels , microspheres , microencapsulation
  • Journal title
    Biomaterials
  • Serial Year
    1998
  • Journal title
    Biomaterials
  • Record number

    542906