Hydroxyapatite–collagen–hyaluronic acid composite

The new composite biomaterial made from hydroxyapatite and collagen conjugated with hyaluronic acid has been studied. The structure evaluation of the composite showed more dense arrangement due to the formation of collagen–hyaluronic acid conjugate, and particles of inorganic component are closely anchored in the structure. Mechanical properties and model swelling of this composite are compared with properties of hydroxyapatite–collagen composite of similar material without hyaluronic acid. Higher cohesivity of the new biomaterial can give new possibilities for application as bone implant material. The test of contact cytotoxicity showed a very good biocompatibility of the biomaterial.