Title of article :
Resorbable bioceramics based on stabilized calcium phosphates. Part II: evaluation of biological response
Author/Authors :
S. Langstaff، نويسنده , , M. Sayer، نويسنده , , T. J. N. Smith، نويسنده , , S. M. Pugh، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
16
From page :
135
To page :
150
Abstract :
Synthetic materials capable of being remodelled in vivo by the same processes responsible for natural bone turnover have long been sought for use as an artificial bone substitute. These materials must ideally combine osteoinductive capacity with the ability to withstand random dissolution at normal physiological pH, while being resorbed by natural cell-mediated processes. Resorbable calcium phosphate based coatings and bulk ceramics have been developed which promote the uniform deposition of new mineralized bone matrix thus enabling rapid integration with the surrounding host bone tissue in vivo. Furthermore, a critical result of this study is the determination that the silicon-stabilized calcium phosphate ceramics are essentially insoluble in biological media but are resorbed when acted upon by osteoclasts. In vitro biological testing and preliminary in vivo testing show that the important features of this new biomaterial are a characteristic calcium phosphate phase composition and a unique microporous morphology.
Keywords :
Osteoclast , resorbable , Tricalcium Phosphate , Hydroxyapatite , orthopedics , Bioceramic
Journal title :
Biomaterials
Serial Year :
2001
Journal title :
Biomaterials
Record number :
543709
Link To Document :
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