Title of article
A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of chitosan
Author/Authors
Jae-Soon Ahn، نويسنده , , Hoo-Kyun Choi، نويسنده , , Chong-Su Cho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
6
From page
923
To page
928
Abstract
A novel mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of chitosan for transmucosal drug delivery system (TMD). FT-IR results indicated that polymer complex was formed between poly(acrylic acid) (PAA) and chitosan through hydrogen bonding. Glass transition temperature (Tg) of chitosan and PAA in the PAA/chitosan polymer complexes was inner-shifted compared with Tg of chitosan and PAA itself. This may be due to the increased miscibility of PAA with chitosan through the hydrogen bonding. The crystallinity of chitosan in the PAA/chitosan polymer complexes was decreased with polymer complex formation with PAA. The dissolution rate of the PAA/chitosan polymer complex was dependent on pH and ratio of PAA/chitosan. The mucoadhesive force of PAA/chitosan polymer complex was similar to a commericial product, Carbopol 971P NF.
Keywords
Mucoadhesive , Template polymerization , Poly(acrylic acid) , Chitosan , adhesive force , Dissolution degree
Journal title
Biomaterials
Serial Year
2001
Journal title
Biomaterials
Record number
543795
Link To Document