• Title of article

    Hydrodynamic function of polyurethane prosthetic heart valves: influences of Youngʹs modulus and leaflet thickness

  • Author/Authors

    Gillian M. Bernacca، نويسنده , , Bernard O’Connor، نويسنده , , David F Williams، نويسنده , , David J. Wheatley، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    6
  • From page
    45
  • To page
    50
  • Abstract
    The development of flexible polyurethane heart valves has been hindered by material degradation in vivo. Low modulus polyurethane leaflets are regarded as desirable to achieve good hydrodynamic function. However, low modulus materials may suffer high strain accumulation, hence poor durability. Higher modulus materials may improve durability, but may have poor hydrodynamic function. This study examines the hydrodynamic behaviour of biostable polyurethane valves, varying Youngʹs modulus from 5 to 63.6 MPa and mean leaflet thickness from 48–238 μm. Parameters studied included mean pressure gradient, energy losses and regurgitation over 5 equivalent cardiac outputs (3.6, 4.9, 6.4, 8.0 and 9.6 l min−1). At low cardiac output, modulus was not significantly correlated with any parameter of valve opening. At 9.6 l min−1, modulus significantly influenced mean pressure gradient (p=0.033). Mean leaflet thickness significantly correlated with mean pressure gradient and energy losses during forward flow at all cardiac outputs (p<0.001). This study demonstrates that, over a wide range of moduli, valve hydrodynamic function is not affected significantly by the material modulus. Leaflet thickness is a highly significant factor. Higher modulus elastomers in a range up to 32.5 MPa may be useful in prosthetic heart valve leaflet manufacture, retaining good hydrodynamic function while potentially extending the lifetime of the valve.
  • Keywords
    Hydrodynamic function , Leaflet thickness , Polyurethane , modulus
  • Journal title
    Biomaterials
  • Serial Year
    2002
  • Journal title
    Biomaterials
  • Record number

    544074