Title of article
In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction
Author/Authors
Sang-Young Lee، نويسنده , , Jung Hwan Oh، نويسنده , , Jae Chan Kim، نويسنده , , Young Ha Kim، نويسنده , , Soo Hyun Kim، نويسنده , , Jung Woo Choi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
11
From page
5049
To page
5059
Abstract
The in vivo reconstruction of conjunctiva was investigated by using modified poly(lactide-co-glycolide) (PLGA) 50/50 scaffolds. The porous PLGA matrices were prepared by a solvent-casting particulate-leaching method with NaCl, then modified with collagen, hyaluronic acid (HA) or/and human amniotic membrane (AM) component. The growth of corneal epithelial cells and human stromal fibroblasts on the scaffolds was investigated in vitro. All the modified PLGA scaffolds demonstrated enhanced cell adhesion and proliferation as compared to PLGA untreated, and the number of cells proliferated after 1 week was increased in the order of PLGA
Keywords
Modified PLGAgraft , Low contraction and scar , Conjunctival reconstruction , Rabbit model
Journal title
Biomaterials
Serial Year
2003
Journal title
Biomaterials
Record number
545148
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