Influence of the concentrations of hyaluronic acid on the properties and biocompatibility of Cs–Gel–HA membranes

The object of this study was to investigate the relationship between the concentrations of HA solutions and the physicochemical properties and the biocompatibility of Cs–Gel–HA membranes. The addition of different concentrations of HA not only improved the wettability significantly and extended the degradation time of Cs–Gel–HA membranes, but also changed their mechanical properties. The concentration of HA had a significant influence on the biocompatibility of Cs–Gel–HA membranes. Results demonstrated that it was only the concentrations of HA in a certain range (0.01–0.1%), that could promote the cell adhesion, migration and proliferation, while the concentration of HA was above 0.1% it would either reduce or even inhibit these behaviors.