Author/Authors :
Patrick H. Warnke، نويسنده , , Jorg Wiltfang، نويسنده , , Ingo Springer، نويسنده , , Yahya Açil، نويسنده , , Hendrik Bolte، نويسنده , , Markus Kosmahl، نويسنده , , Paul A.J. Russo، نويسنده , , Eugene Sherry، نويسنده , , Ulf Lützen، نويسنده , , Stefan Wolfart، نويسنده , , Hendrik Terheyden، نويسنده ,
Abstract :
In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patientʹs experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.
Keywords :
In vivo tissue engineering , replacement , Bone regeneration , bioreactor , BMP , Mandible reconstruction
