Title of article
The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes
Author/Authors
Zoran Markovic، نويسنده , , Biljana Todorovic-Markovic، نويسنده , , Duska Kleut، نويسنده , , Nadezda Nikolic، نويسنده , , Sanja Vranjes-Djuric، نويسنده , , Maja Misirkic، نويسنده , , Ljubica Vucicevic، نويسنده , , Kristina Janjetovic، نويسنده , , Aleksandra Isakovic، نويسنده , , Ljubica Harhaji، نويسنده , , Branka Babic-Stojic، نويسنده , , Miroslav Dramicanin، نويسنده , , Vladimir Trajkovic، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
12
From page
5437
To page
5448
Abstract
Because of the ability to induce cell death in certain conditions, the fullerenes (C60) are potential anticancer and toxic agents. The colloidal suspension of crystalline C60 (nano-C60, nC60) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental analysis and mathematical modelling, we investigate the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC60 suspensions, prepared by solvent exchange method in tetrahydrofuran (THF/nC60) and ethanol (EtOH/nC60), or by extended mixing in water (aqu/nC60). With regard to their capacity to generate ROS and cause mitochondrial depolarization followed by necrotic cell death, the nC60 suspensions are ranked in the following order: THF/nC60>EtOH/nC60>aqu/nC60. Mathematical modelling of singlet oxygen (1O2) generation indicates that the 1O2-quenching power (THF/nC60
Keywords
Modelling , free radical , cytotoxicity , Nanoparticle , carbon
Journal title
Biomaterials
Serial Year
2007
Journal title
Biomaterials
Record number
547827
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