Author/Authors :
Yun-Sang Lee، نويسنده , , Jae Min Jeong، نويسنده , , Young-Joo Kim، نويسنده , , Young Soo Chang and Youngil Kim، نويسنده , , Hak Jeong Lee، نويسنده , , Miwon Son، نويسنده , , Jung Woo Lee، نويسنده , , Heung Sik Yoon، نويسنده , , Won Jun Kang، نويسنده , , Dong Soo Lee، نويسنده , , June-Key Chung، نويسنده , , Myung Chul Lee، نويسنده , , Young-Ger Suh، نويسنده ,
Abstract :
A lipiodol solution of 188Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol (188Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
Keywords :
Liver cancer therapy , HDD , 188Re , lipiodol
