Title of article
Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol
Author/Authors
Yun-Sang Lee، نويسنده , , Jae Min Jeong، نويسنده , , Young-Joo Kim، نويسنده , , Young Soo Chang and Youngil Kim، نويسنده , , Hak Jeong Lee، نويسنده , , Miwon Son، نويسنده , , Jung Woo Lee، نويسنده , , Heung Sik Yoon، نويسنده , , Won Jun Kang، نويسنده , , Dong Soo Lee، نويسنده , , June-Key Chung، نويسنده , , Myung Chul Lee، نويسنده , , Young-Ger Suh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
64
To page
69
Abstract
A lipiodol solution of 188Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol (188Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
Keywords
Liver cancer therapy , HDD , 188Re , lipiodol
Journal title
Applied Radiation and Isotopes
Serial Year
2007
Journal title
Applied Radiation and Isotopes
Record number
548136
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