Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women Original Research Article

The link between serum insulin-like growth factor 1 (IGF-1) and postmenopausal osteoporosis remains controversial. In this study of healthy postmenopausal women, decreased serum concentrations of IGF-1 were strongly associated with an increased risk of osteoporotic fractures indedepently of bone-mineral density.