Title of article :
Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease Original Research Article
Author/Authors :
Alessio Fasano، نويسنده , , Tarcisio Not، نويسنده , , Wenle Wang، نويسنده , , Sergio Uzzau، نويسنده , , Irene Berti، نويسنده , , Alberto Tommasini، نويسنده , , Simeon E Goldblum، نويسنده ,
Abstract :
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.
