Author/Authors :
MJ Arranz، نويسنده , , J Munro، نويسنده , , J Birkett، نويسنده , , A Bolonna، نويسنده , , D Mancama، نويسنده , , M Sodhi، نويسنده , , KP Lesch، نويسنده , , JFW Meyer، نويسنده , , P Sham، نويسنده , , DA Collier، نويسنده , , RM Murray، نويسنده , , RW Kerwin، نويسنده ,
Abstract :
We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76·7% success in the prediction of clozapine response (p = 0·0001) and a sensitivity of 95% (±0·04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.
