Author/Authors :
Gregory J Moore، نويسنده , , Joseph M. Bebchuk، نويسنده , , Ian B. Wilds، نويسنده , , Guang Chen، نويسنده , , Husseini K Menji، نويسنده ,
Abstract :
Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.
