Author/Authors :
Hongxiang Liu، نويسنده , , Agnes Ruskon-Fourmestraux، نويسنده , , Anne Lavergne-Slove، نويسنده , , Hongtao Ye، نويسنده , , Thierry Molina، نويسنده , , Yoram Bouhnik، نويسنده , , Rifat A Hamoudi، نويسنده , , Tim C Diss، نويسنده , , Ahmet Dogan، نويسنده , , Francis Megraud، نويسنده , , Jean Claude Rambaud، نويسنده , , Ming-Qing Du، نويسنده , , Peter G Isaacson، نويسنده ,
Abstract :
20–30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).
