Author/Authors :
Thilo Menges، نويسنده , , Peter WM Hermans، نويسنده , , Simon G Little، نويسنده , , Tanja Langefeld، نويسنده , , Olav B?ning، نويسنده , , J?rg Engel، نويسنده , , Marcel Sluijter، نويسنده , , Ronald de Groot، نويسنده , , Gunter Hempelmann، نويسنده ,
Abstract :
A single base pair insertion/deletion (4G/5G) promoter polymorphism in the plasminogen-activator-inhibitor-1 (PAI-1) gene is thought to play a part in prognosis after severe trauma. We investigated the relation between outcome of severe trauma, PAI-1 concentrationsm, and PAI-1 genotype in 61 patients who had been severely injurd.11 (58%) of 19 patients with genotype 4G/5G did not survive, whereas only eight (28%) of 29 patients with heterozygous genotype 4G/5G, and two (15%) of 13 patients with genotype 5G/5G died. The PAI-1 4G allele is associated with high concentrations of PAI-1 in plasma and a poor survival rate after severe trauma.
