Title of article :
Resistin, central obesity, and type 2 diabetes
Author/Authors :
CL McTernan، نويسنده , , PG McTernan، نويسنده , , AL Harte، نويسنده , , PL Levick، نويسنده , , A.H. Barnett، نويسنده , , S Kumar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
2
From page :
46
To page :
47
Abstract :
Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
Journal title :
The Lancet
Serial Year :
2002
Journal title :
The Lancet
Record number :
555317
Link To Document :
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