Author/Authors :
A Mark Richards، نويسنده , , M. Gary Nicholls، نويسنده , , John G. Lainchbury، نويسنده , , Stephen Fisher، نويسنده , , Timothy G Yandle، نويسنده ,
Abstract :
Urotensin II has vasoconstrictive and negative inotropic effects, suggesting a possible role in circulatory regulation and pathophysiology of heart failure. We developed a sensitive specific RIA and measured plasma urotensin II in patients with heart failure and in controls. Plasma urotensin II was higher in heart failure patients (mean 3•9 pmol/L [SD 1•4]; than in controls (1•9 pmol/L [0•9]; p<0•0001). The role of urotensin II in heart failure, however, has yet to be defined.
