Author/Authors :
Luc Mallet، نويسنده , , Valérie Mesnage، نويسنده , , Jean-Luc Houeto، نويسنده , , Antoine Pélissolo، نويسنده , , Jérôme Yelnik، نويسنده , , Cécile Behar، نويسنده , , Marcella Gargiulo، نويسنده , , Marie-Laure Welter، نويسنده , , Anne-Marie Bonnet، نويسنده , , Bernard Pillon، نويسنده , , Philippe Cornu، نويسنده , , Didier Dormont، نويسنده , , Bernard Pidoux، نويسنده , , Jean-François Allilaire، نويسنده , , Yves Agid، نويسنده ,
Abstract :
Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinsonʹs disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.
