Author/Authors :
Christof Stamm MD، نويسنده , , Bernd Westphal، نويسنده , , Hans-Dieter Kleine، نويسنده , , Michael Petzsch، نويسنده , , Christian Kittner، نويسنده , , Heiko Klinge، نويسنده , , Carl Schümichen، نويسنده , , Christoph A. Nienaber، نويسنده , , Mathias Freund، نويسنده , , Gustav Steinhoff، نويسنده ,
Abstract :
Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×106 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium.
