Title of article :
Telomere maintenance and disease
Author/Authors :
Judy MY Wong، نويسنده , , Kathleen Collins Insel، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
6
From page :
983
To page :
988
Abstract :
The proliferative capacity of human cells is regulated by telomerase, an enzyme uniquely specialised for telomeric DNA synthesis. The critical role of telomerase activation in tumour progression and tumour maintenance has been well established in studies of cancer and of oncogenic transformation in cell culture. New evidence suggests that telomerase activation has an important role in normal somatic cells, and that failure to activate sufficient telomerase also promotes disease. We review the evidence for premature telomere attrition in proliferative deficiencies of the human haemopoietic system, and discuss the potential use of telomerase activation in telomere-restorative gene therapy. Published online May 13, 2003 http://image.thelancet.com/extras/02art7027web.pdf
Journal title :
The Lancet
Serial Year :
2003
Journal title :
The Lancet
Record number :
559646
Link To Document :
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