Author/Authors :
Geoffrey S Gottlieb، نويسنده , , David C Nickle، نويسنده , , Mark J. Jensen، نويسنده , , Kim Ping Wong، نويسنده , , Jandre Grobler، نويسنده , , Fusheng Li، نويسنده , , Shan-Lu Liu، نويسنده , , Cecilia Rademeyer، نويسنده , , Gerald H Learn، نويسنده , , Prof Salim S Abdool Karim، نويسنده , , Carolyn Williamson، نويسنده , , Prof Lawrence Corey، نويسنده , , Prof Joseph B Margolick، نويسنده , , Prof James I Mullins، نويسنده ,
Abstract :
Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per μL was very rapid (<3•4 and <3•1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.
