Author/Authors :
A. R. Zanetti، نويسنده , , S. Paccagnini، نويسنده , , N. Principi، نويسنده , , G. Pizzocolo، نويسنده , , M. L. Caccamo، نويسنده , , E. D. Amico، نويسنده , , G. Cambiè، نويسنده , , L. Vecchi، نويسنده , , the Lombardy Study Group on Vertical HCV Transmission، نويسنده ,
Abstract :
To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p<0·001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p<0·05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.
