Author/Authors :
P. Atkison، نويسنده , , G. Joubert، نويسنده , , Barbara A. Barron، نويسنده , , D. Grant، نويسنده , , John W. Wall، نويسنده , , H. Rosenberg، نويسنده , , J. Howard، نويسنده , , S. Williams، نويسنده , , C. Stiller، نويسنده , , K. Paradis، نويسنده , , E. Seidman، نويسنده ,
Abstract :
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.
