Author/Authors :
K. J. J. Wierenga، نويسنده , , B. E. Serjeant، نويسنده , , G. R. Serjeant، نويسنده , , W. Williams، نويسنده , , M. Miller، نويسنده , , D. J. Shah، نويسنده , , J. R. Pattison، نويسنده , , N. Brink، نويسنده , , M. Griffiths، نويسنده ,
Abstract :
Glomerulonephritis with proteinuria of sufficient degree to manifest the nephrotic syndrome followed aplastic crises induced by human parvovirus (B19) in seven patients with homozygous sickle-cell disease, within 7 days in five patients and 6-7 weeks in two. Segmental proliferative glomerulonephritis was found in all four patients who underwent acute renal biopsies and focal segmental glomerulosclerosis was found in the fifth patient who had a biopsy 4 months later. One patient recovered completely, one died in chronic renal failure after 3 months, and the others had impaired creatinine clearance, four with continuing proteinuria.
