Author/Authors :
J. R. Jass، نويسنده , , D. S. Cottier، نويسنده , , P. Jeevaratnam، نويسنده , , V. Pokos، نويسنده , , K. M. Holdaway، نويسنده , , M. L. Bowden، نويسنده , , N. S. Van de Water، نويسنده , , P. J. Browett، نويسنده ,
Abstract :
50 families with a history of colorectal cancer were divided according to whether criteria for hereditary non-polyposis colorectal cancer (HNPCC) were fulfilled totally (A, N=19) or partly (B, N=31) and stratified by the demonstration that at least half the cancers tested per family were positive for DNA replication errors (RER+). Accepted clinical and pathological characteristics of HNPCC were found to cluster within 12 A/RER+ families in which the mean number of affected individuals per family was 10·1. Reliance upon clinical data alone may result in over-diagnosis of HNPCC, in small families who just meet the minimum criteria, whereas underdiagnosis is rare. The criteria could be refined by inclusion of RER status.
