Interpretation of ambiguous information in clinical depression

The present study used two cognitive tasks—a text comprehension task and a homophone task—to investigate whether clinically depressed individuals have a negative bias when interpreting ambiguous information. Previous research indicates that both tasks are sensitive to anxiety-related interpretive biases, and that the former is less prone to response bias effects. Negative memory biases were also assessed. Results showed that, compared with normal controls, depressed individuals made more negative interpretations on the homophone task, and they also showed an enhanced negative recall bias. However, the groups did not differ in interpretative bias on the text comprehension task. Possible explanations of the results are discussed, including the potential influences of self-referent processing and response bias.