Author/Authors :
Ewa Ellis، نويسنده , , Martin Wagner، نويسنده , , Frank Lammert، نويسنده , , Antal Nemeth، نويسنده , , Judith Gumhold، نويسنده , , Christian P. Strassburg، نويسنده , , Christian Kylander، نويسنده , , Despina Katsika، نويسنده , , Michael Trauner، نويسنده , , Curt Einarsson، نويسنده , , Hanns-Ulrich Marschall، نويسنده ,
Abstract :
We report two patients with uncommon Gilbertʹs syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 μmol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.
Keywords :
Gilbert , Jaundice , Glucuronosyltransferase , Cultured human hepatocytes
