Title of article :
Low doses of insulin-like growth factor-I improve nitrogen retention and food efficiency in rats with early cirrhosis
Author/Authors :
Antonio Picardi، نويسنده , , Admar Costa de Oliveira، نويسنده , , Bego?a Muguerza، نويسنده , , Alicia Tosar، نويسنده , , Jorge Quiroga، نويسنده , , Inma Castilla-Cort?zar، نويسنده , , Santiago Santidri?n، نويسنده , , Jesus Prieto، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
Background/Aims: In order to ascertain whether malnutrition is an early-onset feature of liver cirrhosis and whether the anabolic hormone insulin-like growth factor I (IGF-I) could be useful in the treatment of this complication, we analyzed the nutritional alterations present in rats with early-stage liver cirrhosis and the effects of IGF-I on nutritional parameters in these animals.
Methods: After a 24 h fast, a 15N-enriched diet was administered for 5 days to normal control rats and to cirrhotic rats receiving subcutaneous injections of vehicle (Group 1) or IGF-I, 2 μg•100 g bw−1•day−1, (Group 2) during the 5 experimental days. 15N, a stable N isotope, was measured in biological samples by mass spectrometry.
Results: Compared with control rats, Group 1 animals showed significant reductions in N intake and food efficiency (p<0.05, both). In addition, the weight of the gastrocnemius muscle, its total N content and the dietary N content of this muscle were significantly lower in Group 1 than in control animals (p<0.05, all). In rats from Group 2, mean values of N intake, food efficiency, gastrocnemius N content and the amount of dietary N incorporated into this muscle were similar to those in control rats, and (with the exception of gastrocnemius N total content) significantly higher than those in non-treated cirrhotic rats (p<0.05, all).
Conclusions:A variety of nutritional disturbances were detected in rats from the early stages of liver cirrhosis. Low doses of IGF-I were found to reverse most of these changes. These results stimulate further studies to determine whether IGF-I might be useful in the correction of the malnutrition present in patients with liver cirrhosis.
Keywords :
Nitrogen balance , Stable isotope15N. , N intake , Food efficiency , IGFBP , Insulin-likegrowth factor-I (lGF -I) , Liver cirrhosis , Malnutrition
Journal title :
Journal of Hepatology
Journal title :
Journal of Hepatology