• Title of article

    Hematopoietic stem cell transplantation from non-replicative hepatitis B virus carriers is safe

  • Author/Authors

    Celalettin Ustün، نويسنده , , Ramazan Idilman، نويسنده , , Günhan Gürman، نويسنده , , Muhit ?zcan، نويسنده , , Gülen Akyol، نويسنده , , Hamdi Akan، نويسنده , , Osman Ilhan، نويسنده , , Meral Beksaç، نويسنده , , Akin Uysal، نويسنده , , Nahide Konuk، نويسنده , , Selim Karayalçln، نويسنده , , Aylar Poyraz، نويسنده , , David Van Thiel، نويسنده , , Haluk Koç، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1999
  • Pages
    8
  • From page
    202
  • To page
    209
  • Abstract
    Background/Aims: Hepatitis B virus can cause serious problems in individuals undergoing organ transplantation. The aim of this study was to evaluate the hepatic events among HBs-Ag positive recipients and HBs-Ag negative recipients who received products from hepatitis B virus carriers. Methods: A total of 151 patients received an allogeneic hematopoietic stem cell transplantation at the Department of Hematology-Oncology, University of Ankara, between June 1989 and June 1998. Among these, eight HBs-Ag positive and four HBs-Ag negative recipients received a product from a hepatitis B virus positive donor. The median follow-up period for these 12 patients was 13.2 months. Results: Three of the eight HBs-Ag positive recipients died (one from hepatic failure); of the remainder, two are HBs-Ag negative, two HBs-Ag positive with normal liver injury tests and one HBs-Ag positive with elevated ALT levels. Of the four HBs-Ag negative recipients who received stem cells from a hepatitis B positive donor, two died; none of the patients in this group became HBs-Ag positive after transplantation. Conclusion: Hepatitis B virus infection is a common problem in patients being considered for allogeneic hematopoetic stem cell transplantation, especially in areas where hepatitis B virus infection is endemic. We believe that the presence of HBs-Ag positivity is not an absolute contraindication for allogeneic hematopoetic stem cell transplantation unless the hepatitis B virus is in a replication phase.
  • Keywords
    stem cell transplantation , hepatitis B virus , Immunosnppression , Adoptive immunity , Liver
  • Journal title
    Journal of Hepatology
  • Serial Year
    1999
  • Journal title
    Journal of Hepatology
  • Record number

    584629