Title of article :
Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure
Author/Authors :
Stuart D. Katz، نويسنده , , Kujtim Balidemaj، نويسنده , , Shunichi Homma، نويسنده , , Henry Wu، نويسنده , , Jie Wang، نويسنده , , Simon Maybaum، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
7
From page :
845
To page :
851
Abstract :
OBJECTIVES To determine the acute effects of type 5 phosphodiesterase inhibition with sildenafil on flow-mediated vasodilation in the brachial artery of patients with chronic heart failure. BACKGROUND Impaired endothelium-dependent, flow-mediated vasodilation in patients with heart failure is partly attributable to hyporesponsiveness of cyclic guanosine monophosphate (cGMP) mediated vasorelaxation effector mechanisms in vascular smooth muscle. The effect of inhibition of cGMP degradation with sildenafil, a specific type 5 cGMP phosphodiesterase inhibitor, on flow-mediated dilation in heart failure is unknown. METHODS Flow-mediated vasodilation after release of 1, 3 and 5 min of transient arterial occlusion was measured in the brachial artery with high resolution two-dimensional ultrasound imaging in 48 patients with chronic heart failure before and 1 h after randomized, double-blind assignment to a single oral dose of sildenafil 12.5, 25 or 50 mg or matching placebo. RESULTS In response to oral administration of a single dose of study drug, the change in flow-mediated vasodilation after release of 1, 3 and 5 min of arterial occlusion was significantly greater in patients receiving sildenafil 25 mg (3.3 ± 1.9, 3.8 ± 1.8 and 4.0 ± 1.8%, respectively, p < 0.05) and patients receiving sildenafil 50 mg (3.7 ± 1.3, 4.1 ± 1.1, 3.9 ± 1.3%, respectively, p < 0.05) than that of patients receiving placebo (0.7 ± 1.1, 0.2 ± 1.2, 0.6 ± 0.8%, respectively). CONCLUSIONS Acute type 5 phosphodiesterase inhibition with sildenafil 25 and 50 mg increases endothelium-dependent, flow-mediated vasodilation in patients with chronic heart failure when compared with placebo.
Journal title :
JACC (Journal of the American College of Cardiology)
Serial Year :
2000
Journal title :
JACC (Journal of the American College of Cardiology)
Record number :
596086
Link To Document :
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