Title of article :
Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women
Author/Authors :
Maria G. Modena، نويسنده , , Lorenzo Bonetti، نويسنده , , Francesca Coppi، نويسنده , , Francesca Bursi، نويسنده , , Rosario Rossi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
6
From page :
505
To page :
510
Abstract :
Objectives The aim of the present study was to assess whether optimized antihypertensive treatment is effective in modifying endothelial function and whether an improvement in flow-mediated vasodilation (FMD) in response to treatment, as an expression of reversible endothelial dysfunction, could predict a more favorable prognosis in a population of postmenopausal women. Background Hypertensive postmenopausal women have been shown to have abnormal endothelium-dependent vascular function. However, FMD may change over time, according to antihypertensive treatment; the prognostic value of these changes has not been investigated. Methods A total of 400 consecutive postmenopausal women with mild-to-moderate hypertension and impaired FMD underwent ultrasonography of the brachial artery at baseline and after six months, while optimal control of blood pressure was achieved using antihypertensive therapy. They were then followed up for a mean period of 67 months (range 57 to 78). Endothelial function was measured as FMD of the brachial artery, using high-resolution ultrasound. Results After six months of treatment, FMD had not changed (≤10% relative to baseline) in 150 (37.5%) of 400 women (group 1), whereas it had significantly improved (>10% relative to baseline) in the remaining 250 women (62.5%) (group 2). During follow-up, we noticed 32 events (3.50 per 100 person-years) in group 1 and 15 events (0.51 per 100 person-years) in group 2 (p < 0.0001). Conclusions This study demonstrates that a significant improvement in endothelial function may be obtained after six months of antihypertensive therapy and clearly identifies patients who possibly have a more favorable prognosis.
Keywords :
BP , blood pressure , FMD , flow-mediated dilation , flow-mediated vasodilation , JNC-V , Fifth Joint National Committee on Detection , evaluation , and Treatment of High Blood Pressure , NO , nitric oxide , tissue-type plasminogen activator , u-PA , bad , urokinase-type plasminogen activator , brachial artery diameter , t-PA
Journal title :
JACC (Journal of the American College of Cardiology)
Serial Year :
2002
Journal title :
JACC (Journal of the American College of Cardiology)
Record number :
597430
Link To Document :
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