Author/Authors :
Giuseppe G. L. Biondi-Zoccai، نويسنده , , Antonio Abbate، نويسنده , , Giovanna Liuzzo، نويسنده , , Luigi M. Biasucci، نويسنده ,
Abstract :
Diabetes represents a major cause of cardiovascular morbidity and mortality in developed countries, and atherothrombosis accounts for most deaths among diabetics. Recent evidence has reliably shown the relevant etiopathogenetic role of inflammation in atherothrombotic disease. This review summarizes and discusses the possible synergistic effects of diabetes and inflammation in promoting atherothrombosis and its complications, as well as potential avenues for diagnostic, preventive, and therapeutic benefits in the modulation of inflammatory mechanisms in diabetic atherothrombotic disease.
Keywords :
NF-kappa-B , nuclear factor-kappa-B , AGEP , NO , CRP , PAI-1 , Advanced glycation end products , nitric oxide , C-reactive protein , plasminogen activator inhibitor-1 , HDL , PPAR , high-density lipoprotein , peroxisome proliferator-activated receptor , ICAM-1 , TNF-alpha , I-kappa-B , VCAM-1 , intercellular adhesion molecule-1 , Tumor necrosis factor-alpha , NF-kappa-B–inhibiting protein , vascular cell adhesion molecule-1 , Interleukin , IL , LDL , low-density lipoprotein
