Title of article :
Effect of supplemental phytonutrients on impairment of the flow-mediated brachialartery vasoactivity after a single high-fat meal
Author/Authors :
Gary D. Plotnick، نويسنده , , Mary C. Corretti، نويسنده , , Robert A. Vogel، نويسنده , , Robert Hesslink Jr، نويسنده , , John A. Wise، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
6
From page :
1744
To page :
1749
Abstract :
Objectives Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide. Background Ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least 4 h; however, co-ingestion of vitamin antioxidants or a green salad has been shown to prevent this effect. Methods Flow-mediated brachial artery reactivity test (BART) both before and 3 h after a 900 calorie 50 g fat meal was evaluated in 38 healthy volunteers (age 36.4 ± 10.1 years). Subjects were randomized to four weeks of daily supplementation with a powdered fruit vegetable juice concentrate (Juice Plus [JP]) along with a complex supplement providing nutritional antioxidants and various herbal extracts (Vineyard [V]), JP alone, or a matching placebo. At three and four weeks, BART was repeated both before and after the high-fat meal. Serum nitrate/nitrite concentrations were measured at baseline and at four weeks. Results Four weeks of the JP-V combination blunted the detrimental effect of the high-fat meal (−47.5 ± 23.4% at baseline vs. −1.7 ± 9.7% at four weeks [p < 0.05]). Four weeks of JP alone had a similar beneficial effect (−45.1 ± 19.7% at baseline vs. −16.6 ± 10.3% at four weeks [p < 0.05]), whereas there was no substantial effect of the placebo. In the subjects treated with supplements, concentrations of serum nitrate/nitrite increased from 78 ± 39 to 114 ± 62 μm/l (p < 0.02). Conclusions Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration.
Keywords :
BART , brachial artery reactivity test , FMV , flow-mediated vasodilation , JP , LDL , V , low-density lipoprotein , NAD(P)H , nicotinamide adenine dinucleotide phosphate (reduced) , NO , Juice Plus , nitric oxide , vineyard
Journal title :
JACC (Journal of the American College of Cardiology)
Serial Year :
2003
Journal title :
JACC (Journal of the American College of Cardiology)
Record number :
597985
Link To Document :
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