Author/Authors :
Menno Huikeshoven، نويسنده , , Johan F. Beek، نويسنده , , Jos A. P. van der Sloot، نويسنده , , Raymond Tukkie، نويسنده , , Jan van der Meulen، نويسنده , , Martin J. C. van Gemert، نويسنده ,
Abstract :
In the past 35 years many experimental studies have been performed to investigate the revascularization potential of transmyocardial revascularization and the possible working mechanisms underlying the observed clinical improvement in angina pectoris after this treatment. In this review of the experimental literature, the various methods that have been used to create transmyocardial channels and the most supported hypotheses on the working mechanism (channel patency, angiogenesis and myocardial denervation) are discussed and evaluated.
