Author/Authors :
Masao Takahashi، نويسنده , , Takuro Misaki، نويسنده , , Go Watanabe، نويسنده , , Hiroshi Ohtake، نويسنده , , Yoshio Tsunezuka، نويسنده , , Masanari Wada، نويسنده , , Naoki Sakakibara، نويسنده , , Yasuhiro Matsunaga، نويسنده , , Michio Kawasuji، نويسنده , , Yoh Watanabe، نويسنده ,
Abstract :
In this study, we examined the capability of a skeletal muscle—powered, dynamic patch to provide left ventricular assistance. An actuator was developed that used linear traction power furnished by the latissimus dorsi muscle and liquid as the medium for power transfer. The proximal portion of the muscle was dissected and was reattached to the actuator. The left ventricular apex was excised, and the dynamic patch lined with autologous pericardium was implanted during cardiopulmonary bypass. Hemodynamic studies were performed in 8 dogs after weaning from cardiopulmonary bypass. Muscle stimulation was found to significantly increase the systolic aortic pressure (91.6 versus 112.1 mm Hg; p < 0.01), the mean aortic pressure (65.2 versus 73.0 mm Hg; p < 0.01), and aortic blood flow (0.77 versus 0.92 L/min; p < 0.01). The left atrial pressure decreased from 17.9 to 16.6 mm Hg (p < 0.01). This “hybrid” left ventricular assist device possesses notable clinical advantages because of its remarkable efficacy in assisting circulation. Further experimental studies using preconditioned skeletal muscle are necessary to assess the long-term effects of this technique.
