Title of article :
Cardiac xenotransplantation: clinical experience and future direction
Author/Authors :
David H. Adams، نويسنده , , Raymond H. Chen، نويسنده , , Alexander Kadner، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
7
From page :
320
To page :
326
Abstract :
The shortage of human organs has focused research on finding an animal source of replacement organs. The immunological barriers to xenotransplantation are now more clearly defined, allowing retrospective interpretation of past clinical experience in humans. Due to physiological compatibilities as well as ethical and infectious considerations, pigs have now emerged as the most likely source of future xenografts. The introduction of transgenic pigs expressing human complement regulatory proteins and new immunosuppressive regimens have shown early promise in the laboratory, although further advancements are needed to advance to clinical trials. Additional clarification of infectious risks and patient strategies are remaining obstacles to application in the clinical arena.
Journal title :
The Annals of Thoracic Surgery
Serial Year :
2000
Journal title :
The Annals of Thoracic Surgery
Record number :
616973
Link To Document :
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