Author/Authors :
Lorraine Tafra، نويسنده , , Zandra Cheng، نويسنده , , Joseph Uddo، نويسنده , , Mary B. Lobrano، نويسنده , , William Stein، نويسنده , , Wendie A. Berg، نويسنده , , Edward Levine، نويسنده , , Irving N. Weinberg، نويسنده , , Deepa Narayanan، نويسنده , , Eric Ross PhD، نويسنده , , David Beylin، نويسنده , , Stephen Yarnall، نويسنده , , Rochelle Keen، نويسنده , , Kristen Sawyer، نويسنده , , Jack Van Geffen، نويسنده , , Rita L. Freimanis، نويسنده , , Edward Staab، نويسنده , , Lee P. Adler، نويسنده , , Judy Lovelace، نويسنده , , Perry Shen، نويسنده , , et al.، نويسنده ,
Abstract :
Background
High-resolution positron-emission mammography (PEM) is a new device, which allows the imaging of breast tissue. A prospective study was performed to assess the accuracy of PEM in newly diagnosed breast cancer patients.
Methods
In a prospective multicenter study, 44 women with confirmed breast cancers were imaged with a high-resolution PEM scanner (Naviscan PET Systems, Rockville, MD) with 18F-fluorodeoxyglucose. The images were blindly evaluated and were compared with final pathology.
Results
The majority of the index lesions were seen on PEM (89%, 39/44). PEM detected 4 of 5 incidental breast cancers, 3 of which were not seen by any other imaging modalities. Of 19 patients undergoing breast-conserving surgery, PEM correctly predicted 6 of 8 (75%) patients with positive margins and 100% (11/11) with negative margins.
Conclusion
The current PEM device shows promise in detecting breast malignancies and may assist in the planning of adequate partial mastectomy procedures to better ensure negative margins.
