Title of article :
Exacerbation of acute pancreatitis by combined cholinergic stimulation and duct obstruction
Author/Authors :
Isaac Samuel، نويسنده , , Ashok Chaudhary، نويسنده , , Rory A. Fisher، نويسنده , , Raymond J. Joehl، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
4
From page :
721
To page :
724
Abstract :
Background The role of cholinergic pathways in the pathogenesis of bile-pancreatic duct ligation (BPDL)-induced acute pancreatitis in rats remains controversial. We hypothesized that cholinergic stimulation exacerbates acute pancreatic inflammation in the presence of duct obstruction. Methods We studied 34 rats divided into 5 groups as follows: (1) sham operation; (2) BPDL; (3) BPDL with duodenal bile-pancreatic juice (BPJ) replacement fresh from a donor rat; (4) BPDL with BPJ replacement as in 3 above, and carbachol (CCh) 5 ug/h subcutaneously; or (5) CCh 5 ug/h subcutaneously only. Rats were killed after 6 hours. Results The P value was less than .05 by analysis of variance. Pancreatic morphologic changes and zymogen fraction hyperamylasemia seen with duct ligation (2 vs. 1) were ameliorated significantly by duodenal BPJ replacement (3 vs. 2), but not when exogenous CCh was administered (4 vs. 3), whereas CCh alone showed no significant changes compared with sham (5 vs. 1). Conclusions Cholinergic stimulation and duct obstruction synergistically amplify acinar hyperstimulation and exacerbate acute pancreatitis.
Keywords :
zymogen , Cholinergic receptor , Acinar cell , CCK-A receptor , donor rat model , Acute pancreatitis
Journal title :
The American Journal of Surgery
Serial Year :
2005
Journal title :
The American Journal of Surgery
Record number :
618098
Link To Document :
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