Regulation of Albumin mRNA and Its Promoter-binding Nuclear Factors under Different Perioperative Nutritional Methods in Hepatectomized Rats

Background: Regulation of perioperative albumin synthesis under parenteral (PN) and enteral (EN) nutrition was investigated. Methods: Rats were divided into PN and EN groups. Both groups received the same regimen of artificial nutrition for 7 days and then underwent 70% hepatectomy. Serum albumin and mRNA levels of albumin and its promoter-binding nuclear factors (C/EBPα, β, and DBP) were measured. Results: Serum albumin and albumin mRNA in the PN group were significantly lower than those in the EN group at 72 hours after hepatectomy. Preoperative and postoperative DBP and C/EBPα mRNA levels in the EN group were significantly higher than those in the PN group. Conclusion: Serum albumin was well maintained by EN after hepatectomy owing to an early recovery of albumin mRNA level and its nuclear factor mRNA levels (C/EBPα and DBP). Compared with PN, EN is a more advantageous from of perioperative nutrition as pertains to albumin synthesis.