Intraoperative Intracameral Carbachol in Phacoemulification and Poterior Chamber Len Implantation

Purpoe: To evaluate the ue of intraoperative intracameral carbachol in aociation with phacoemulification and poterior len implantation. Method: We propectively randomly aigned 41 eye (41 patient) to receive either placebo or a 50:50 dilution of carbachol 0.01% after intraocular len inertion and phacoemulification. Reult: Twenty-one eye of 21 patient treated with intracameral carbachol howed a tatitically ignificant (P = .0373) reduction in intraocular preure (15.9 mm Hg) at 6 hour potoperatively compared with 20 eye of 20 patient who had received placebo (20.4 mm Hg). At day 1, the carbachol group meaured 15.0 mm Hg v 17.6 mm Hg for placebo (P = .0376), and a 1.5-line improvement in viual acuity in the carbachol v the placebo group wa noted (P = .0263), which wa maintained on glare teting. On quality of life teting uing a modified F-36 tet, carbachol-treated patient within the firt potoperative week more often attempted to decend tair in both bright (P = .007) and dim (P = .037) light than did patient treated with placebo. At month 2, no difference wa oberved between group except that depth of focu wa tatitically greater in the carbachol group (P = .025). afety wa imilar between the two group in term of ocular and ytemic advere event. Concluion: Patient treated with carbachol intracamerally after phacoemulification and poterior chamber len implantation demontrate lower intraocular preure within the firt day potoperatively. Thee finding are aociated with improved viual acuity and potentially greater ambulation in bright light within the firt potoperative week.