Randomized trial of intraoperative mitomycin c in urgery for pterygium

Purpoe: To report the efficacy and afety of intraoperative application of mitomycin C in urgery for pterygium. Method: In a propective randomized and double-blind tudy done within a pan of 2.5 year in 50 eye (50 patient) with primary progreive pterygium, mitomycin C in a concentration of 0.02 mg/ml oaked in a terile 5 × 5-mm ponge wa applied over the bare clera intraoperatively a an adjuvant therapy in 25 eye after pterygium exciion. Thee cae were compared with another 25 imilar eye that underwent the ame procedure but in which gentamicin olution 0.3% wa ued intead of mitomycin C olution. Reult: Three eye (12%) in the mitomycin C group howed recurrence within 7 month of urgery compared with eight eye (32%) of the gentamicin control group within 3 to 5 month. Mild ide effect, uch a pain, photophobia, and delayed wound healing, were oberved within the firt 1 to 2 week potoperatively in both group. In the mitomycin C-treated group, corneal change in the form of uperficial punctate keratiti (three eye) and limbal avacularity (two eye) ubided within 2 week potoperatively. Followup time for thee cae ranged from 18 to 21 month. Concluion: A diluted olution of mitomycin C, 0.02 mg/ml, with an accurate ize of terile ponge applied to bare ciera after primary pterygium exciion decreae the rate of recurrence to a greater extent than doe gentamicin olution and i not aociated with evere complication