Primary glaucoma triple procedure in patient with primary open-angle glaucoma: The effect of mitomycin C in patient with and without prognotic factor for filtration failure Original Reearch Article

Purpoe To invetigate the effect of adjunctive mitomycin C on primary glaucoma triple procedure in patient with primary open-angle glaucoma with and without one or more of the prognotic factor for filtration failure of primary glaucoma triple procedure. Thoe factor include being of African-American race, having a preoperative intraocular preure of 20 mm Hg or more on maximum tolerated medication, and being on two or more medication preoperatively. Method tudy patient conited of 197 conecutive patient with primary open-angle glaucoma who were randomly aigned to receive either no adjunctive mitomycin C (101 eye of 101 patient) or to receive adjunctive ubconjunctival mitomycin C (96 eye of 96 patient) during the primary glaucoma triple procedure. Kaplan-Meier urvival analyi comparion were made between repective ubgroup with and without prognotic indicator for filtration failure uing a relatively tringent et of criteria for filtration ucce of primary glaucoma triple procedure. Reult There wa no tatitically ignificant (P = .117) difference in filtration ucce of primary glaucoma triple procedure between the control and mitomycin C group. Adjunctive mito-mycin C ignificantly (P < .05) improved the filtration outcome of the primary glaucoma triple procedure in the ubgroup with each of the three prognotic factor for filtration failure of primary glaucoma triple procedure. On the other hand, in the ubgroup without the prognotic factor, adjunctive mitomycin C did not ignificantly (P > .05) change the filtration outcome of the primary glaucoma triple procedure. Concluion Thee finding etablih the bai for elective ue of mitomycin C in patient with primary open-angle glaucoma undergoing primary glaucoma triple procedure.